Cargando…

Novel suppressors of α-synuclein toxicity identified using yeast

The mechanism by which the Parkinson’s disease-related protein α-synuclein (α-syn) causes neurodegeneration has not been elucidated. To determine the genes that protect cells from α-syn, we used a genetic screen to identify suppressors of the super sensitivity of the yeast Saccharomyces cerevisiae e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Jun, Clark-Dixon, Cheryl, Wang, Shaoxiao, Flower, Todd R., Williams-Hart, Tara, Zweig, Richard, Robinson, Lucy C., Tatchell, Kelly, Witt, Stephan N.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581432/ https://www.ncbi.nlm.nih.gov/pubmed/18772193 http://dx.doi.org/10.1093/hmg/ddn276

Ejemplares similares

YGR198w (YPP1) targets A30P α-synuclein to the vacuole for degradation
por: Flower, Todd R., et al.
Publicado: (2007)

Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease
por: Lee, Yong Joo, et al.
Publicado: (2011)

The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling - a possible implication for methamphetamine use?
por: Wang, Shaoxiao, et al.
Publicado: (2014)

Rapid Selection of Cyclic Peptides that Reduce α-Synuclein Toxicity in Yeast and Animal Models
por: Kritzer, Joshua A., et al.
Publicado: (2009)

Suppressors of ipl1-2 in Components of a Glc7 Phosphatase Complex, Cdc48 AAA ATPase, TORC1, and the Kinetochore
por: Robinson, Lucy C., et al.
Publicado: (2012)

Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast
por: Del Vecchio, Mara, et al.
Publicado: (2023)

Sumoylation Protects Against β-Synuclein Toxicity in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2018)

The effect of copy number on α-synuclein’s toxicity and its protective role in Bax-induced apoptosis, in yeast
por: Akintade, Damilare D., et al.
Publicado: (2020)

Cerium Oxide Nanoparticles Rescue α-Synuclein-Induced Toxicity in a Yeast Model of Parkinson’s Disease
por: Ruotolo, Roberta, et al.
Publicado: (2020)

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2015)

Sumoylation inhibits α-synuclein aggregation and toxicity
por: Krumova, Petranka, et al.
Publicado: (2011)

The Role of Glial Mitochondria in α-Synuclein Toxicity
por: Jeon, Yu-Mi, et al.
Publicado: (2020)

Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
por: Shan, Frank Y., et al.
Publicado: (2021)

Sorting Out the Role of α-Synuclein in Retromer-Mediated Endosomal Protein Sorting
por: Patel, Dhaval, et al.
Publicado: (2018)

Direct α-synuclein promoter transactivation by the tumor suppressor p53
por: Duplan, Eric, et al.
Publicado: (2016)

A novel yeast‐based screening system for potential compounds that can alleviate human α‐synuclein toxicity
por: Sangkaew, Anyaporn, et al.
Publicado: (2021)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
por: Rajasekaran, Santhanasabapathy, et al.
Publicado: (2021)

Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
por: Roberts, Hazel L., et al.
Publicado: (2015)

Role of mitochondria in α-synuclein mediated neuronal toxicity
por: Pai, Sadashiva K.
Publicado: (2023)

Neuronal identity defines α-synuclein and tau toxicity
por: Praschberger, Roman, et al.
Publicado: (2023)

The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy
por: Gupta, Arpit, et al.
Publicado: (2018)

Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae
por: Prasai, Kanchanjunga, et al.
Publicado: (2017)

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease
por: Schneider, Jay S., et al.
Publicado: (2019)

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
por: Gupta, Vijay, et al.
Publicado: (2020)

Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system
por: De Graeve, Stijn, et al.
Publicado: (2013)

α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1
por: Sampaio‐Marques, Belém, et al.
Publicado: (2019)

Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy
por: Chawla, Srishti, et al.
Publicado: (2023)

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
por: Cremades, Nunilo, et al.
Publicado: (2012)

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
por: Cascella, Roberta, et al.
Publicado: (2019)

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2021)

NOS1AP Interacts with α-Synuclein and Aggregates in Yeast and Mammalian Cells
por: Matiiv, Anton B., et al.
Publicado: (2022)

High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast
por: Huang, Yi, et al.
Publicado: (2017)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
por: Santos, Jaime, et al.
Publicado: (2021)

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
por: Butler, Erin K., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9534u5ivrvs0r2b84ekrbi6pqu