Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting ∼10% of early-onset dementia patients. Here we expand the role of GRN in FTLD-U and demonstrate that a...

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Detalles Bibliográficos
Autores principales: Rademakers, Rosa, Eriksen, Jason L., Baker, Matt, Robinson, Todd, Ahmed, Zeshan, Lincoln, Sarah J., Finch, Nicole, Rutherford, Nicola J., Crook, Richard J., Josephs, Keith A., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Parisi, Joseph E., Caselli, Richard J., Wszolek, Zbigniew K., Uitti, Ryan J., Feldman, Howard, Hutton, Michael L., Mackenzie, Ian R., Graff-Radford, Neill R., Dickson, Dennis W.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581433/
https://www.ncbi.nlm.nih.gov/pubmed/18723524
http://dx.doi.org/10.1093/hmg/ddn257

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