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Synaptotagmin C2B Domain Regulates Ca(2+)-triggered Fusion in Vitro: CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS

Synaptotagmin (syt) 1 is localized to synaptic vesicles, binds Ca(2+), and regulates neuronal exocytosis. Syt 1 harbors two Ca(2+)-binding motifs referred to as C2A and C2B. In this study we examine the function of the isolated C2 domains of Syt 1 using a reconstituted, SNARE (soluble N-ethylmaleimi...

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Detalles Bibliográficos
Autores principales:	Gaffaney, Jon D., Dunning, F. Mark, Wang, Zhao, Hui, Enfu, Chapman, Edwin R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581593/ https://www.ncbi.nlm.nih.gov/pubmed/18784080 http://dx.doi.org/10.1074/jbc.M803355200

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