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De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
The pluripotency determining gene, Oct-3/4 (also called Pou5f1) undergoes post implantation silencing in a process mediated by the histone methyltransferase (HMT) G9a. Microarray analysis now shows that this enzyme may operate as a master regulator that inactivates multiple early embryonic genes by...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581722/ https://www.ncbi.nlm.nih.gov/pubmed/18953337 http://dx.doi.org/10.1038/nsmb.1476 |