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A PI3-Kinase–Mediated Negative Feedback Regulates Neuronal Excitability

Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies, such as epilepsy, but the precise mechanisms by which t...

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Detalles Bibliográficos
Autores principales:	Howlett, Eric, Lin, Curtis Chun-Jen, Lavery, William, Stern, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581892/ https://www.ncbi.nlm.nih.gov/pubmed/19043547 http://dx.doi.org/10.1371/journal.pgen.1000277

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