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Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

BACKGROUND: Oxidative stress and inflammation are two critical factors that drive the formation of plaques in atherosclerosis. Nrf2 is a redox-sensitive transcription factor that upregulates a battery of antioxidative genes and cytoprotective enzymes that constitute the cellular response to oxidativ...

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Detalles Bibliográficos
Autores principales:	Sussan, Thomas E., Jun, Jonathan, Thimmulappa, Rajesh, Bedja, Djahida, Antero, Maria, Gabrielson, Kathleen L., Polotsky, Vsevolod Y., Biswal, Shyam
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582492/ https://www.ncbi.nlm.nih.gov/pubmed/19023427 http://dx.doi.org/10.1371/journal.pone.0003791

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