Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism

Sterol regulatory element binding protein-1c (SREBP-1c) is a basic helix–loop–helix (bHLH) homodimeric transactivator, which induces itself and several lipogenic enzymes, notably fatty acid synthase (FAS). We demonstrated that hypoxia-inducible factor (HIF) represses the SREBP-1c gene by inducing St...

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Detalles Bibliográficos
Autores principales: Choi, Su Mi, Cho, Hyun-Ju, Cho, Heesang, Kim, Kang Ho, Kim, Jae Bum, Park, Hyunsung
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582599/
https://www.ncbi.nlm.nih.gov/pubmed/18838394
http://dx.doi.org/10.1093/nar/gkn620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582599/
https://www.ncbi.nlm.nih.gov/pubmed/18838394
http://dx.doi.org/10.1093/nar/gkn620

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