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Structural explanation for the role of Mn(2+) in the activity of ϕ6 RNA-dependent RNA polymerase
The biological role of manganese (Mn(2+)) has been a long-standing puzzle, since at low concentrations it activates several polymerases whilst at higher concentrations it inhibits. Viral RNA polymerases possess a common architecture, reminiscent of a closed right hand. The RNA-dependent RNA polymera...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582606/ https://www.ncbi.nlm.nih.gov/pubmed/18940872 http://dx.doi.org/10.1093/nar/gkn632 |