Transcription elongation past O(6)-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase

O(6)-Methylguanine (O(6)-meG) is a major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous methylating agents. We report the results of transcription past a site-specifically modified O(6)-meG DNA template by bacteriophage T7 RNA polymerase and human RNA p...

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Detalles Bibliográficos
Autores principales: Dimitri, Alexandra, Burns, John A., Broyde, Suse, Scicchitano, David A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582612/
https://www.ncbi.nlm.nih.gov/pubmed/18854351
http://dx.doi.org/10.1093/nar/gkn657

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