The assembly of a spliceosomal small nuclear ribonucleoprotein particle

The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and fun...

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Detalles Bibliográficos
Autores principales: Patel, Snehal Bhikhu, Bellini, Michel
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582628/
https://www.ncbi.nlm.nih.gov/pubmed/18854356
http://dx.doi.org/10.1093/nar/gkn658
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author Patel, Snehal Bhikhu
Bellini, Michel
author_facet Patel, Snehal Bhikhu
Bellini, Michel
author_sort Patel, Snehal Bhikhu
collection PubMed
description The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and function of spliceosomal snRNPs have been extensively studied. Accordingly, the functions of splicing snRNPs and the role of various nuclear organelles, such as Cajal bodies (CBs), in their nuclear maturation phase have already been excellently reviewed elsewhere. The aim of this review is, then, to briefly outline the structure of snRNPs and to synthesize new and exciting developments in the snRNP biogenesis pathways.
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spelling pubmed-25826282008-11-13 The assembly of a spliceosomal small nuclear ribonucleoprotein particle Patel, Snehal Bhikhu Bellini, Michel Nucleic Acids Res Survey and Summary The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and function of spliceosomal snRNPs have been extensively studied. Accordingly, the functions of splicing snRNPs and the role of various nuclear organelles, such as Cajal bodies (CBs), in their nuclear maturation phase have already been excellently reviewed elsewhere. The aim of this review is, then, to briefly outline the structure of snRNPs and to synthesize new and exciting developments in the snRNP biogenesis pathways. Oxford University Press 2008-11 2008-10-14 /pmc/articles/PMC2582628/ /pubmed/18854356 http://dx.doi.org/10.1093/nar/gkn658 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Patel, Snehal Bhikhu
Bellini, Michel
The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title_full The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title_fullStr The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title_full_unstemmed The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title_short The assembly of a spliceosomal small nuclear ribonucleoprotein particle
title_sort assembly of a spliceosomal small nuclear ribonucleoprotein particle
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582628/
https://www.ncbi.nlm.nih.gov/pubmed/18854356
http://dx.doi.org/10.1093/nar/gkn658
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