Is the anti-psychotic, 10-(3-(dimethylamino)propyl)phenothiazine (promazine), a potential drug with which to treat SARS infections?: Lack of efficacy of promazine on SARS-CoV replication in a mouse model

Phenothiazine and derivatives were tested for inhibition of SARS-CoV replication. Phenothiazine slightly inhibited SARS-CoV replication in a neutral red (NR) uptake assay. Adding a propylamino group to give promazine reduced virus yields (VYR assay) with an EC(90) = 8.3 ± 2.8 μM, but without selecti...

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Detalles Bibliográficos
Autores principales: Barnard, Dale L., Day, Craig W., Bailey, Kevin, Heiner, Matthew, Montgomery, Robert, Lauridsen, Larry, Jung, Kie-Hoon, Li, Joseph K.-K., Chan, Paul K.S., Sidwell, Robert W.
Formato: Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582943/
https://www.ncbi.nlm.nih.gov/pubmed/18423639
http://dx.doi.org/10.1016/j.antiviral.2007.12.005

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