Cargando…

Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study

Electrophysiological studies have suggested that the activity of the primary motor cortex (M1) during ipsilateral hand movement reflects both the ipsilateral innervation and the transcallosal inhibitory control from its counterpart in the opposite hemisphere, and that their asymmetry might cause han...

Descripción completa

Detalles Bibliográficos
Autores principales: Hayashi, Masamichi J., Saito, Daisuke N., Aramaki, Yu, Asai, Tatsuya, Fujibayashi, Yasuhisa, Sadato, Norihiro
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583153/
https://www.ncbi.nlm.nih.gov/pubmed/18413350
http://dx.doi.org/10.1093/cercor/bhn053
_version_ 1782160733560111104
author Hayashi, Masamichi J.
Saito, Daisuke N.
Aramaki, Yu
Asai, Tatsuya
Fujibayashi, Yasuhisa
Sadato, Norihiro
author_facet Hayashi, Masamichi J.
Saito, Daisuke N.
Aramaki, Yu
Asai, Tatsuya
Fujibayashi, Yasuhisa
Sadato, Norihiro
author_sort Hayashi, Masamichi J.
collection PubMed
description Electrophysiological studies have suggested that the activity of the primary motor cortex (M1) during ipsilateral hand movement reflects both the ipsilateral innervation and the transcallosal inhibitory control from its counterpart in the opposite hemisphere, and that their asymmetry might cause hand dominancy. To examine the asymmetry of the involvement of the ipsilateral motor cortex during a unimanual motor task under frequency stress, we conducted block-design functional magnetic resonance imaging with 22 normal right-handed subjects. The task involved visually cued unimanual opponent finger movement at various rates. The contralateral M1 showed symmetric frequency-dependent activation. The ipsilateral M1 showed task-related deactivation at low frequencies without laterality. As the frequency of the left-hand movement increased, the left M1 showed a gradual decrease in the deactivation. This data suggests a frequency-dependent increased involvement of the left M1 in ipsilateral hand control. By contrast, the right M1 showed more prominent deactivation as the frequency of the right-hand movement increased. This suggests that there is an increased transcallosal inhibition from the left M1 to the right M1, which overwhelms the right M1 activation during ipsilateral hand movement. These results demonstrate the dominance of the left M1 in both ipsilateral innervation and transcallosal inhibition in right-handed individuals.
format Text
id pubmed-2583153
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-25831532009-02-25 Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study Hayashi, Masamichi J. Saito, Daisuke N. Aramaki, Yu Asai, Tatsuya Fujibayashi, Yasuhisa Sadato, Norihiro Cereb Cortex Articles Electrophysiological studies have suggested that the activity of the primary motor cortex (M1) during ipsilateral hand movement reflects both the ipsilateral innervation and the transcallosal inhibitory control from its counterpart in the opposite hemisphere, and that their asymmetry might cause hand dominancy. To examine the asymmetry of the involvement of the ipsilateral motor cortex during a unimanual motor task under frequency stress, we conducted block-design functional magnetic resonance imaging with 22 normal right-handed subjects. The task involved visually cued unimanual opponent finger movement at various rates. The contralateral M1 showed symmetric frequency-dependent activation. The ipsilateral M1 showed task-related deactivation at low frequencies without laterality. As the frequency of the left-hand movement increased, the left M1 showed a gradual decrease in the deactivation. This data suggests a frequency-dependent increased involvement of the left M1 in ipsilateral hand control. By contrast, the right M1 showed more prominent deactivation as the frequency of the right-hand movement increased. This suggests that there is an increased transcallosal inhibition from the left M1 to the right M1, which overwhelms the right M1 activation during ipsilateral hand movement. These results demonstrate the dominance of the left M1 in both ipsilateral innervation and transcallosal inhibition in right-handed individuals. Oxford University Press 2008-12 2008-04-15 /pmc/articles/PMC2583153/ /pubmed/18413350 http://dx.doi.org/10.1093/cercor/bhn053 Text en © 2008 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Hayashi, Masamichi J.
Saito, Daisuke N.
Aramaki, Yu
Asai, Tatsuya
Fujibayashi, Yasuhisa
Sadato, Norihiro
Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title_full Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title_fullStr Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title_full_unstemmed Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title_short Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study
title_sort hemispheric asymmetry of frequency-dependent suppression in the ipsilateral primary motor cortex during finger movement: a functional magnetic resonance imaging study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583153/
https://www.ncbi.nlm.nih.gov/pubmed/18413350
http://dx.doi.org/10.1093/cercor/bhn053
work_keys_str_mv AT hayashimasamichij hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy
AT saitodaisuken hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy
AT aramakiyu hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy
AT asaitatsuya hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy
AT fujibayashiyasuhisa hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy
AT sadatonorihiro hemisphericasymmetryoffrequencydependentsuppressionintheipsilateralprimarymotorcortexduringfingermovementafunctionalmagneticresonanceimagingstudy