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The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song...
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Formato: | Texto |
Lenguaje: | English |
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Cell Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583281/ https://www.ncbi.nlm.nih.gov/pubmed/17716899 http://dx.doi.org/10.1016/j.cub.2007.07.047 |
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author | Rideout, Elizabeth J. Billeter, Jean-Christophe Goodwin, Stephen F. |
author_facet | Rideout, Elizabeth J. Billeter, Jean-Christophe Goodwin, Stephen F. |
author_sort | Rideout, Elizabeth J. |
collection | PubMed |
description | Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song production [7]. Our examination of one of these regions, the mesothoracic ganglion (Msg), revealed the coexpression of two sex-determination genes, fruitless (fru) and doublesex (dsx). Because both genes are involved in creating a sexually dimorphic CNS [8, 9] and are necessary for song production [10–13], we investigated the individual contributions of fru and dsx to the specification of a male CNS and song production. We show a novel requirement for dsx in specifying a sexually dimorphic population of fru-expressing neurons in the Msg. Moreover, by using females constitutively expressing the male-specific isoforms of fru (Fru(M)), we show a critical requirement for the male isoform of dsx (Dsx(M)), alongside Fru(M), in the specification of courtship song. Therefore, although Fru(M) expression is sufficient for the performance of many male-specific behaviors [14], we have shown that without Dsx(M), the determination of a male-specific CNS and thus a full complement of male behaviors are not realized. |
format | Text |
id | pubmed-2583281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25832812008-11-17 The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song Rideout, Elizabeth J. Billeter, Jean-Christophe Goodwin, Stephen F. Curr Biol Report Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song production [7]. Our examination of one of these regions, the mesothoracic ganglion (Msg), revealed the coexpression of two sex-determination genes, fruitless (fru) and doublesex (dsx). Because both genes are involved in creating a sexually dimorphic CNS [8, 9] and are necessary for song production [10–13], we investigated the individual contributions of fru and dsx to the specification of a male CNS and song production. We show a novel requirement for dsx in specifying a sexually dimorphic population of fru-expressing neurons in the Msg. Moreover, by using females constitutively expressing the male-specific isoforms of fru (Fru(M)), we show a critical requirement for the male isoform of dsx (Dsx(M)), alongside Fru(M), in the specification of courtship song. Therefore, although Fru(M) expression is sufficient for the performance of many male-specific behaviors [14], we have shown that without Dsx(M), the determination of a male-specific CNS and thus a full complement of male behaviors are not realized. Cell Press 2007-09-04 /pmc/articles/PMC2583281/ /pubmed/17716899 http://dx.doi.org/10.1016/j.cub.2007.07.047 Text en © 2007 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Report Rideout, Elizabeth J. Billeter, Jean-Christophe Goodwin, Stephen F. The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title | The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title_full | The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title_fullStr | The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title_full_unstemmed | The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title_short | The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song |
title_sort | sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583281/ https://www.ncbi.nlm.nih.gov/pubmed/17716899 http://dx.doi.org/10.1016/j.cub.2007.07.047 |
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