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The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song

Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song...

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Detalles Bibliográficos
Autores principales: Rideout, Elizabeth J., Billeter, Jean-Christophe, Goodwin, Stephen F.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583281/
https://www.ncbi.nlm.nih.gov/pubmed/17716899
http://dx.doi.org/10.1016/j.cub.2007.07.047
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author Rideout, Elizabeth J.
Billeter, Jean-Christophe
Goodwin, Stephen F.
author_facet Rideout, Elizabeth J.
Billeter, Jean-Christophe
Goodwin, Stephen F.
author_sort Rideout, Elizabeth J.
collection PubMed
description Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song production [7]. Our examination of one of these regions, the mesothoracic ganglion (Msg), revealed the coexpression of two sex-determination genes, fruitless (fru) and doublesex (dsx). Because both genes are involved in creating a sexually dimorphic CNS [8, 9] and are necessary for song production [10–13], we investigated the individual contributions of fru and dsx to the specification of a male CNS and song production. We show a novel requirement for dsx in specifying a sexually dimorphic population of fru-expressing neurons in the Msg. Moreover, by using females constitutively expressing the male-specific isoforms of fru (Fru(M)), we show a critical requirement for the male isoform of dsx (Dsx(M)), alongside Fru(M), in the specification of courtship song. Therefore, although Fru(M) expression is sufficient for the performance of many male-specific behaviors [14], we have shown that without Dsx(M), the determination of a male-specific CNS and thus a full complement of male behaviors are not realized.
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spelling pubmed-25832812008-11-17 The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song Rideout, Elizabeth J. Billeter, Jean-Christophe Goodwin, Stephen F. Curr Biol Report Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating species-specific information [1–6]. Sex mosaic studies have shown that the sex of certain regions of the central nervous system (CNS) is critical to song production [7]. Our examination of one of these regions, the mesothoracic ganglion (Msg), revealed the coexpression of two sex-determination genes, fruitless (fru) and doublesex (dsx). Because both genes are involved in creating a sexually dimorphic CNS [8, 9] and are necessary for song production [10–13], we investigated the individual contributions of fru and dsx to the specification of a male CNS and song production. We show a novel requirement for dsx in specifying a sexually dimorphic population of fru-expressing neurons in the Msg. Moreover, by using females constitutively expressing the male-specific isoforms of fru (Fru(M)), we show a critical requirement for the male isoform of dsx (Dsx(M)), alongside Fru(M), in the specification of courtship song. Therefore, although Fru(M) expression is sufficient for the performance of many male-specific behaviors [14], we have shown that without Dsx(M), the determination of a male-specific CNS and thus a full complement of male behaviors are not realized. Cell Press 2007-09-04 /pmc/articles/PMC2583281/ /pubmed/17716899 http://dx.doi.org/10.1016/j.cub.2007.07.047 Text en © 2007 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Report
Rideout, Elizabeth J.
Billeter, Jean-Christophe
Goodwin, Stephen F.
The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title_full The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title_fullStr The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title_full_unstemmed The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title_short The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song
title_sort sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583281/
https://www.ncbi.nlm.nih.gov/pubmed/17716899
http://dx.doi.org/10.1016/j.cub.2007.07.047
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