Allele dependent silencing of COL1A2 using small interfering RNAs

Osteogenesis imperfecta (OI) is generally caused by a dominant mutation in Collagen I, encoded by the genes COL1A1 and COL1A2. To date there is no satisfactory therapy for OI, but inactivation of the mutant allele through small interfering RNAs (siRNA) is a promising approach, as siRNAs targeting ea...

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Detalles Bibliográficos
Autores principales: Lindahl, Katarina, Rubin, Carl-Johan, Kindmark, Andreas, Ljunggren, Östen
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2008
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583335/
https://www.ncbi.nlm.nih.gov/pubmed/19015742

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