Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect on the molecu...

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Detalles Bibliográficos
Autores principales: Schmidt, Steffen, Gerasimova, Anna, Kondrashov, Fyodor A., Adzuhbei, Ivan A., Kondrashov, Alexey S., Sunyaev, Shamil
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583910/
https://www.ncbi.nlm.nih.gov/pubmed/19043566
http://dx.doi.org/10.1371/journal.pgen.1000281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583910/
https://www.ncbi.nlm.nih.gov/pubmed/19043566
http://dx.doi.org/10.1371/journal.pgen.1000281

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