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Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?

We aimed to investigate the effects of creatine (Cr) supplementation on the plasma lipid profile in sedentary male subjects undergoing aerobic training. Subjects (n = 22) were randomly divided into two groups and were allocated to receive treatment with either creatine monohydrate (CR) (~20 g·day(-1...

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Autores principales: Gualano, Bruno, Ugrinowitsch, Carlos, Artioli, Guilherme G, Benatti, Fabiana B, Scagliusi, Fernanda B, Harris, Roger C, Lancha, Antonio H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583972/
https://www.ncbi.nlm.nih.gov/pubmed/18831767
http://dx.doi.org/10.1186/1550-2783-5-16
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author Gualano, Bruno
Ugrinowitsch, Carlos
Artioli, Guilherme G
Benatti, Fabiana B
Scagliusi, Fernanda B
Harris, Roger C
Lancha, Antonio H
author_facet Gualano, Bruno
Ugrinowitsch, Carlos
Artioli, Guilherme G
Benatti, Fabiana B
Scagliusi, Fernanda B
Harris, Roger C
Lancha, Antonio H
author_sort Gualano, Bruno
collection PubMed
description We aimed to investigate the effects of creatine (Cr) supplementation on the plasma lipid profile in sedentary male subjects undergoing aerobic training. Subjects (n = 22) were randomly divided into two groups and were allocated to receive treatment with either creatine monohydrate (CR) (~20 g·day(-1 )for one week followed by ~10 g·day(-1 )for a further eleven weeks) or placebo (PL) (dextrose) in a double blind fashion. All subjects undertook moderate intensity aerobic training during three 40-minute sessions per week, over 3 months. High-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL), total cholesterol (TC), triglyceride (TAG), fasting insulin and fasting glycemia were analyzed in plasma. Thereafter, the homeostasis model assessment (HOMA) was calculated. Tests were performed at baseline (Pre) and after four (Post 4), eight (Post 8) and twelve (Post 12) weeks. We observed main time effects in both groups for HDL (Post 4 versus Post 8; P = 0.01), TAG and VLDL (Pre versus Post 4 and Post 8; P = 0.02 and P = 0.01, respectively). However, no between group differences were noted in HDL, LDL, CT, VLDL and TAG. Additionally, fasting insulin, fasting glycemia and HOMA did not change significantly. These findings suggest that Cr supplementation does not exert any additional effect on the improvement in the plasma lipid profile than aerobic training alone.
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spelling pubmed-25839722008-11-18 Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training? Gualano, Bruno Ugrinowitsch, Carlos Artioli, Guilherme G Benatti, Fabiana B Scagliusi, Fernanda B Harris, Roger C Lancha, Antonio H J Int Soc Sports Nutr Research Article We aimed to investigate the effects of creatine (Cr) supplementation on the plasma lipid profile in sedentary male subjects undergoing aerobic training. Subjects (n = 22) were randomly divided into two groups and were allocated to receive treatment with either creatine monohydrate (CR) (~20 g·day(-1 )for one week followed by ~10 g·day(-1 )for a further eleven weeks) or placebo (PL) (dextrose) in a double blind fashion. All subjects undertook moderate intensity aerobic training during three 40-minute sessions per week, over 3 months. High-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL), total cholesterol (TC), triglyceride (TAG), fasting insulin and fasting glycemia were analyzed in plasma. Thereafter, the homeostasis model assessment (HOMA) was calculated. Tests were performed at baseline (Pre) and after four (Post 4), eight (Post 8) and twelve (Post 12) weeks. We observed main time effects in both groups for HDL (Post 4 versus Post 8; P = 0.01), TAG and VLDL (Pre versus Post 4 and Post 8; P = 0.02 and P = 0.01, respectively). However, no between group differences were noted in HDL, LDL, CT, VLDL and TAG. Additionally, fasting insulin, fasting glycemia and HOMA did not change significantly. These findings suggest that Cr supplementation does not exert any additional effect on the improvement in the plasma lipid profile than aerobic training alone. BioMed Central 2008-10-03 /pmc/articles/PMC2583972/ /pubmed/18831767 http://dx.doi.org/10.1186/1550-2783-5-16 Text en Copyright © 2008 Gualano et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gualano, Bruno
Ugrinowitsch, Carlos
Artioli, Guilherme G
Benatti, Fabiana B
Scagliusi, Fernanda B
Harris, Roger C
Lancha, Antonio H
Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title_full Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title_fullStr Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title_full_unstemmed Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title_short Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
title_sort does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583972/
https://www.ncbi.nlm.nih.gov/pubmed/18831767
http://dx.doi.org/10.1186/1550-2783-5-16
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