Cargando…

PTTG: an important target gene for ovarian cancer therapy

Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Panguluri, Siva Kumar, Yeakel, Casey, Kakar, Sham S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584053/
https://www.ncbi.nlm.nih.gov/pubmed/19014669
http://dx.doi.org/10.1186/1757-2215-1-6
_version_ 1782160770008612864
author Panguluri, Siva Kumar
Yeakel, Casey
Kakar, Sham S
author_facet Panguluri, Siva Kumar
Yeakel, Casey
Kakar, Sham S
author_sort Panguluri, Siva Kumar
collection PubMed
description Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice. The PTTG expression levels have been correlated with tumor progression, invasion, and metastasis. Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth, suggesting its important role in tumorigenesis. In this review, we focus on PTTG structure, sub-cellular distribution, cellular functions, and role in tumor progression with suggestions on possible exploration of this gene for cancer therapy.
format Text
id pubmed-2584053
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-25840532008-11-18 PTTG: an important target gene for ovarian cancer therapy Panguluri, Siva Kumar Yeakel, Casey Kakar, Sham S J Ovarian Res Review Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice. The PTTG expression levels have been correlated with tumor progression, invasion, and metastasis. Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth, suggesting its important role in tumorigenesis. In this review, we focus on PTTG structure, sub-cellular distribution, cellular functions, and role in tumor progression with suggestions on possible exploration of this gene for cancer therapy. BioMed Central 2008-10-20 /pmc/articles/PMC2584053/ /pubmed/19014669 http://dx.doi.org/10.1186/1757-2215-1-6 Text en Copyright © 2008 Panguluri et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Panguluri, Siva Kumar
Yeakel, Casey
Kakar, Sham S
PTTG: an important target gene for ovarian cancer therapy
title PTTG: an important target gene for ovarian cancer therapy
title_full PTTG: an important target gene for ovarian cancer therapy
title_fullStr PTTG: an important target gene for ovarian cancer therapy
title_full_unstemmed PTTG: an important target gene for ovarian cancer therapy
title_short PTTG: an important target gene for ovarian cancer therapy
title_sort pttg: an important target gene for ovarian cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584053/
https://www.ncbi.nlm.nih.gov/pubmed/19014669
http://dx.doi.org/10.1186/1757-2215-1-6
work_keys_str_mv AT pangulurisivakumar pttganimportanttargetgeneforovariancancertherapy
AT yeakelcasey pttganimportanttargetgeneforovariancancertherapy
AT kakarshams pttganimportanttargetgeneforovariancancertherapy