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PTTG: an important target gene for ovarian cancer therapy
Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584053/ https://www.ncbi.nlm.nih.gov/pubmed/19014669 http://dx.doi.org/10.1186/1757-2215-1-6 |
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author | Panguluri, Siva Kumar Yeakel, Casey Kakar, Sham S |
author_facet | Panguluri, Siva Kumar Yeakel, Casey Kakar, Sham S |
author_sort | Panguluri, Siva Kumar |
collection | PubMed |
description | Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice. The PTTG expression levels have been correlated with tumor progression, invasion, and metastasis. Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth, suggesting its important role in tumorigenesis. In this review, we focus on PTTG structure, sub-cellular distribution, cellular functions, and role in tumor progression with suggestions on possible exploration of this gene for cancer therapy. |
format | Text |
id | pubmed-2584053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25840532008-11-18 PTTG: an important target gene for ovarian cancer therapy Panguluri, Siva Kumar Yeakel, Casey Kakar, Sham S J Ovarian Res Review Pituitary tumor transforming gene (PTTG), also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation, DNA repair, organ development, and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice. The PTTG expression levels have been correlated with tumor progression, invasion, and metastasis. Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth, suggesting its important role in tumorigenesis. In this review, we focus on PTTG structure, sub-cellular distribution, cellular functions, and role in tumor progression with suggestions on possible exploration of this gene for cancer therapy. BioMed Central 2008-10-20 /pmc/articles/PMC2584053/ /pubmed/19014669 http://dx.doi.org/10.1186/1757-2215-1-6 Text en Copyright © 2008 Panguluri et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Panguluri, Siva Kumar Yeakel, Casey Kakar, Sham S PTTG: an important target gene for ovarian cancer therapy |
title | PTTG: an important target gene for ovarian cancer therapy |
title_full | PTTG: an important target gene for ovarian cancer therapy |
title_fullStr | PTTG: an important target gene for ovarian cancer therapy |
title_full_unstemmed | PTTG: an important target gene for ovarian cancer therapy |
title_short | PTTG: an important target gene for ovarian cancer therapy |
title_sort | pttg: an important target gene for ovarian cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584053/ https://www.ncbi.nlm.nih.gov/pubmed/19014669 http://dx.doi.org/10.1186/1757-2215-1-6 |
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