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Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

OBJECTIVE—Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes. RESEARCH DESIGN AND METHODS—Confluent...

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Detalles Bibliográficos
Autores principales:	Xie, Zhonglin, Zhang, Junhua, Wu, Jiliang, Viollet, Benoit, Zou, Ming-Hui
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584127/ https://www.ncbi.nlm.nih.gov/pubmed/18835932 http://dx.doi.org/10.2337/db08-0610

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