Cargando…

Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy

OBJECTIVE—White adipose tissue is a critical regulator of whole-body glucose metabolism. Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits adipocyte differentiation, both in vitro and in vivo. In this study, we have investigated the effects of Pref-1 overexpression on whole-body glu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villena, Josep A., Choi, Cheol Soo, Wang, Yuhui, Kim, Sheene, Hwang, Yu-Jin, Kim, Young-Bum, Cline, Gary, Shulman, Gerald I., Sul, Hei Sook
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Obesity Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584131/ https://www.ncbi.nlm.nih.gov/pubmed/18835937 http://dx.doi.org/10.2337/db07-1739

Ejemplares similares

Pref-1, a Gatekeeper of Adipogenesis
por: Hudak, Carolyn S., et al.
Publicado: (2013)

Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1(+) to PDGFRα(+) Cells
por: Gulyaeva, Olga, et al.
Publicado: (2018)

A pref-1-controlled non-inflammatory mechanism of insulin resistance
por: Huang, Yiheng, et al.
Publicado: (2023)

Membrane-Tethered Delta-Like 1 Homolog (DLK1) Restricts Adipose Tissue Size by Inhibiting Preadipocyte Proliferation
por: Mortensen, Sussi B., et al.
Publicado: (2012)

Retinoic Acid Upregulates Preadipocyte Genes to Block Adipogenesis and Suppress Diet-Induced Obesity
por: Berry, Daniel C., et al.
Publicado: (2012)

Untangling the Heterogeneity of Acquired Generalized Lipodystrophy
por: Cavdar, Umit, et al.
Publicado: (2021)

FRI054 Partial Lipodystrophy As A Manifestation Of Autoimmune Polyglandular Syndrome 1
por: Agarwal, Shubham, et al.
Publicado: (2023)

Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells
por: Rhee, Marie, et al.
Publicado: (2016)

Inhibition of Angiopoietin-Like 3 (ANGPTL3) Reduces Adipose Tissue Insulin Resistance in Patients With Familial Partial Lipodystrophy
por: de Freitas, Maria Cristina Foss, et al.
Publicado: (2021)

Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy
por: Brasil, Brandao Bruna, et al.
Publicado: (2022)

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance
por: Krieg, Laura, et al.
Publicado: (2022)

SUN-610 Acquired Generalized Lipodystrophy: A Rare Side Effect of PD1-Inhibitor Therapy
por: Shah, Amy, et al.
Publicado: (2020)

Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance
por: Perfield, James W., et al.
Publicado: (2011)

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
por: Lee, Yun Sok, et al.
Publicado: (2011)

The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms
por: da Silva, Carina, et al.
Publicado: (2020)

SUN-109 PTEN Regulates Differentiation and Proliferation of Aging Preadipocytes
por: Kirstein, Anna, et al.
Publicado: (2019)

SAT674 Lipodystrophy: A Hidden Culprit In Uncontrolled Diabetes
por: Sayed, Farah El, et al.
Publicado: (2023)

Dietary Micronutrients Reduce Insulin Resistance via Adipose Tissue Modulation in Mice Fed a High Fat Diet
por: Yang, Zeyu, et al.
Publicado: (2022)

Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates
por: Thorn, Stephanie R., et al.
Publicado: (2014)

Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs
por: Malbert, Charles-Henri, et al.
Publicado: (2020)

Intake of Resistant Starch Reduces Colonic Inflammation in the Colon of Obese, C57BL/6 Mice Fed a High Fat Diet
por: Zeng, Huawei, et al.
Publicado: (2022)

Leptin Decreases Energy Expenditure but Increases Thyroid Hormone in Patients With Lipodystrophy
por: Quaye, Emmanuel, et al.
Publicado: (2021)

Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders
por: Kim, Chu-Sook, et al.
Publicado: (2011)

SUN-607 Iron Parameters in Patients with Partial Lipodystrophy and Impact of Metreleptin Therapy
por: Boutros, Sabine, et al.
Publicado: (2020)

Novel Heterozygous LMNA Variants Causing Familial Partial Lipodystrophy, Dunnigan Variety
por: Wadhwa, Akhilesh, et al.
Publicado: (2021)

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia
por: Kursawe, Romy, et al.
Publicado: (2013)

P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
por: Sato, Chikage, et al.
Publicado: (2011)

Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
por: Wang, Hong, et al.
Publicado: (2009)

Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance
por: Kang, Hong Soon, et al.
Publicado: (2011)

PSUN81 A novel case of congenital generalized lipodystrophy (CGL) with no genetic abnormalites in the AGPAT2, BSCL2, CAV1, and CAVIN1 genes.
por: Mericq, Veronica, et al.
Publicado: (2022)

Enrichment of Tc1 cells and T cell resistance to suppression are associated with dysglycemia in the visceral fat in human obesity
por: Cardellini, Sara, et al.
Publicado: (2020)

Metabolic Improvements After Gastric Sleeve Surgery in a Patient With Familial Partial Lipodystrophy
por: Niaz, Azra, et al.
Publicado: (2021)

FRI056 Effect Of 48 Hour Of Metreleptin In Humans With Lipodystrophy During Controlled Feeding
por: Bukhari, Khulood M, et al.
Publicado: (2023)

SAT676 Severe Recurrent Pancreatitis In A Familial Partial Lipodystrophy Patient On Metreleptin
por: Sargin, Pinar, et al.
Publicado: (2023)

Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
por: Algieri, Cristina, et al.
Publicado: (2022)

Glucagon-like Peptide-1 Receptor Analogues for the Treatment of Obesity
por: Williams, David M, et al.
Publicado: (2022)

Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity
por: Macia, Laurence, et al.
Publicado: (2012)

Caveolae-Associated Protein 3 (Cavin-3) Influences Adipogenesis via TACE-Mediated Pref-1 Shedding
por: Park, Phil June, et al.
Publicado: (2020)

MON-100 Unique miRNA Signature in HIV Lipodystrophy with Reduced Adipose Dicer Expression
por: Srinivasa, Suman, et al.
Publicado: (2019)

SAT652 The Expression Of The Immunoproteasome Subunit Psmb9 Is Related To Obesity And The Differentiation Of Human Preadipocytes
por: Cui, Yan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_c6g2scoofpilfimjblv8s02gko