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Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1–Selective K(+) Channel Opener?

OBJECTIVE— In glucose-sensing neurons, ATP-sensitive K(+) channels (K(ATP) channels) are thought to translate metabolic signals into an alteration in neuronal firing rates. Because these neurons express the Kir6.2/SUR-1 isoform of the K(ATP) channel, we sought to examine the therapeutic potential of...

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Detalles Bibliográficos
Autores principales:	Fan, Xiaoning, Ding, Yuyan, Cheng, Haiying, Gram, Dorte X., Sherwin, Robert S., McCrimmon, Rory J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584140/ https://www.ncbi.nlm.nih.gov/pubmed/18776135 http://dx.doi.org/10.2337/db08-0793

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