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Depression: An Important Comorbidity With Metabolic Syndrome in a General Population

OBJECTIVE—There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in a sample representative of the general population whether depression, anxiety, and psychological distress are associated with metabolic syndrome and its compone...

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Autores principales: Dunbar, James A., Reddy, Prasuna, Davis-Lameloise, Nathalie, Philpot, Benjamin, Laatikainen, Tiina, Kilkkinen, Annamari, Bunker, Stephen J., Best, James D., Vartiainen, Erkki, Kai Lo, Sing, Janus, Edward D.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584197/
https://www.ncbi.nlm.nih.gov/pubmed/18835951
http://dx.doi.org/10.2337/dc08-0175
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author Dunbar, James A.
Reddy, Prasuna
Davis-Lameloise, Nathalie
Philpot, Benjamin
Laatikainen, Tiina
Kilkkinen, Annamari
Bunker, Stephen J.
Best, James D.
Vartiainen, Erkki
Kai Lo, Sing
Janus, Edward D.
author_facet Dunbar, James A.
Reddy, Prasuna
Davis-Lameloise, Nathalie
Philpot, Benjamin
Laatikainen, Tiina
Kilkkinen, Annamari
Bunker, Stephen J.
Best, James D.
Vartiainen, Erkki
Kai Lo, Sing
Janus, Edward D.
author_sort Dunbar, James A.
collection PubMed
description OBJECTIVE—There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in a sample representative of the general population whether depression, anxiety, and psychological distress are associated with metabolic syndrome and its components. RESEARCH DESIGN AND METHODS—Three cross-sectional surveys including clinical health measures were completed in rural regions of Australia during 2004–2006. A stratified random sample (n = 1,690, response rate 48%) of men and women aged 25–84 years was selected from the electoral roll. Metabolic syndrome was defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III (NCEP ATP III), and International Diabetes Federation (IDF) criteria. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale and psychological distress by the Kessler 10 measure. RESULTS—Metabolic syndrome was associated with depression but not psychological distress or anxiety. Participants with the metabolic syndrome had higher scores for depression (n = 409, mean score 3.41, 95% CI 3.12–3.70) than individuals without the metabolic syndrome (n = 936, mean 2.95, 95% CI 2.76–3.13). This association was also present in 338 participants with the metabolic syndrome and without diabetes (mean score 3.37, 95% CI 3.06–3.68). Large waist circumference and low HDL cholesterol showed significant and independent associations with depression. CONCLUSIONS—Our results show an association between metabolic syndrome and depression in a heterogeneous sample. The presence of depression in individuals with the metabolic syndrome has implications for clinical management.
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spelling pubmed-25841972009-12-01 Depression: An Important Comorbidity With Metabolic Syndrome in a General Population Dunbar, James A. Reddy, Prasuna Davis-Lameloise, Nathalie Philpot, Benjamin Laatikainen, Tiina Kilkkinen, Annamari Bunker, Stephen J. Best, James D. Vartiainen, Erkki Kai Lo, Sing Janus, Edward D. Diabetes Care Cardiovascular and Metabolic Risk OBJECTIVE—There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in a sample representative of the general population whether depression, anxiety, and psychological distress are associated with metabolic syndrome and its components. RESEARCH DESIGN AND METHODS—Three cross-sectional surveys including clinical health measures were completed in rural regions of Australia during 2004–2006. A stratified random sample (n = 1,690, response rate 48%) of men and women aged 25–84 years was selected from the electoral roll. Metabolic syndrome was defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III (NCEP ATP III), and International Diabetes Federation (IDF) criteria. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale and psychological distress by the Kessler 10 measure. RESULTS—Metabolic syndrome was associated with depression but not psychological distress or anxiety. Participants with the metabolic syndrome had higher scores for depression (n = 409, mean score 3.41, 95% CI 3.12–3.70) than individuals without the metabolic syndrome (n = 936, mean 2.95, 95% CI 2.76–3.13). This association was also present in 338 participants with the metabolic syndrome and without diabetes (mean score 3.37, 95% CI 3.06–3.68). Large waist circumference and low HDL cholesterol showed significant and independent associations with depression. CONCLUSIONS—Our results show an association between metabolic syndrome and depression in a heterogeneous sample. The presence of depression in individuals with the metabolic syndrome has implications for clinical management. American Diabetes Association 2008-12 /pmc/articles/PMC2584197/ /pubmed/18835951 http://dx.doi.org/10.2337/dc08-0175 Text en Copyright © 2008, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Cardiovascular and Metabolic Risk
Dunbar, James A.
Reddy, Prasuna
Davis-Lameloise, Nathalie
Philpot, Benjamin
Laatikainen, Tiina
Kilkkinen, Annamari
Bunker, Stephen J.
Best, James D.
Vartiainen, Erkki
Kai Lo, Sing
Janus, Edward D.
Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title_full Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title_fullStr Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title_full_unstemmed Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title_short Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
title_sort depression: an important comorbidity with metabolic syndrome in a general population
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584197/
https://www.ncbi.nlm.nih.gov/pubmed/18835951
http://dx.doi.org/10.2337/dc08-0175
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