Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are depen...

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Autores principales: Vickaryous, N, Polanco-Echeverry, G, Morrow, S, Suraweera, N, Thomas, H, Tomlinson, I, Silver, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584943/
https://www.ncbi.nlm.nih.gov/pubmed/18941465
http://dx.doi.org/10.1038/sj.bjc.6604737
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author Vickaryous, N
Polanco-Echeverry, G
Morrow, S
Suraweera, N
Thomas, H
Tomlinson, I
Silver, A
author_facet Vickaryous, N
Polanco-Echeverry, G
Morrow, S
Suraweera, N
Thomas, H
Tomlinson, I
Silver, A
author_sort Vickaryous, N
collection PubMed
description We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).
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spelling pubmed-25849432009-11-04 Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome Vickaryous, N Polanco-Echeverry, G Morrow, S Suraweera, N Thomas, H Tomlinson, I Silver, A Br J Cancer Genetics and Genomics We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+). Nature Publishing Group 2008-11-04 2008-10-21 /pmc/articles/PMC2584943/ /pubmed/18941465 http://dx.doi.org/10.1038/sj.bjc.6604737 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Vickaryous, N
Polanco-Echeverry, G
Morrow, S
Suraweera, N
Thomas, H
Tomlinson, I
Silver, A
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title_full Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title_fullStr Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title_full_unstemmed Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title_short Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
title_sort smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584943/
https://www.ncbi.nlm.nih.gov/pubmed/18941465
http://dx.doi.org/10.1038/sj.bjc.6604737
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