Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice

At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angio...

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Autores principales: Pantaleo, M A, Astolfi, A, Nannini, M, Paterini, P, Piazzi, G, Ercolani, G, Brandi, G, Martinelli, G, Pession, A, Pinna, A D, Biasco, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584956/
https://www.ncbi.nlm.nih.gov/pubmed/18827815
http://dx.doi.org/10.1038/sj.bjc.6604681
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author Pantaleo, M A
Astolfi, A
Nannini, M
Paterini, P
Piazzi, G
Ercolani, G
Brandi, G
Martinelli, G
Pession, A
Pinna, A D
Biasco, G
author_facet Pantaleo, M A
Astolfi, A
Nannini, M
Paterini, P
Piazzi, G
Ercolani, G
Brandi, G
Martinelli, G
Pession, A
Pinna, A D
Biasco, G
author_sort Pantaleo, M A
collection PubMed
description At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
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spelling pubmed-25849562009-11-04 Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice Pantaleo, M A Astolfi, A Nannini, M Paterini, P Piazzi, G Ercolani, G Brandi, G Martinelli, G Pession, A Pinna, A D Biasco, G Br J Cancer Genetics and Genomics At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways. Nature Publishing Group 2008-11-04 2008-09-30 /pmc/articles/PMC2584956/ /pubmed/18827815 http://dx.doi.org/10.1038/sj.bjc.6604681 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Pantaleo, M A
Astolfi, A
Nannini, M
Paterini, P
Piazzi, G
Ercolani, G
Brandi, G
Martinelli, G
Pession, A
Pinna, A D
Biasco, G
Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title_full Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title_fullStr Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title_full_unstemmed Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title_short Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
title_sort gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584956/
https://www.ncbi.nlm.nih.gov/pubmed/18827815
http://dx.doi.org/10.1038/sj.bjc.6604681
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