p16 Mutation Spectrum in the Premalignant Condition Barrett's Esophagus

BACKGROUND: Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions. METHODS A...

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Detalles Bibliográficos
Autores principales: Paulson, Thomas G., Galipeau, Patricia C., Xu, Lianjun, Kissel, Heather D., Li, Xiaohong, Blount, Patricia L., Sanchez, Carissa A., Odze, Robert D., Reid, Brian J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585012/
https://www.ncbi.nlm.nih.gov/pubmed/19043591
http://dx.doi.org/10.1371/journal.pone.0003809

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