Heterologous Replacement of the Supposed Host Determining Region of Avihepadnaviruses: High In Vivo Infectivity Despite Low Infectivity for Hepatocytes

Hepadnaviruses, including hepatitis B virus (HBV), a highly relevant human pathogen, are small enveloped DNA viruses that replicate via reverse transcription. All hepadnaviruses display a narrow tissue and host tropism. For HBV, this restricts efficient experimental in vivo infection to chimpanzees....

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Detalles Bibliográficos
Autores principales: Dallmeier, Kai, Schultz, Ursula, Nassal, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585059/
https://www.ncbi.nlm.nih.gov/pubmed/19057662
http://dx.doi.org/10.1371/journal.ppat.1000230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585059/
https://www.ncbi.nlm.nih.gov/pubmed/19057662
http://dx.doi.org/10.1371/journal.ppat.1000230

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