Absence of human herpes virus-8 (HHV8) in nephrogenic systemic fibrosis

BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma. FINDINGS: Skin lesions procured from two male NSF patients were found to be negative for HHV8 (L...

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Detalles Bibliográficos
Autores principales: O'Donnell, Patrick J, Duke, Wayne H, Pantanowitz, Liron
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Data Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585090/
https://www.ncbi.nlm.nih.gov/pubmed/18799006
http://dx.doi.org/10.1186/1756-0500-1-82
Descripción
Sumario:BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma. FINDINGS: Skin lesions procured from two male NSF patients were found to be negative for HHV8 (LNA-1) by means of immunohistochemsitry. CONCLUSION: This finding negates a role for HHV8 in the pathogenesis of NSF.

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