Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying spermatozoa. Our data demonstrated that in heterozygous males, the expression of I-PpoI in the testes induced a strong bias towa...

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Detalles Bibliográficos
Autores principales: Windbichler, Nikolai, Papathanos, Philippos Aris, Crisanti, Andrea
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585807/
https://www.ncbi.nlm.nih.gov/pubmed/19057670
http://dx.doi.org/10.1371/journal.pgen.1000291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585807/
https://www.ncbi.nlm.nih.gov/pubmed/19057670
http://dx.doi.org/10.1371/journal.pgen.1000291

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