Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells

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Immunoglobulin heavy chain class switch recombination (CSR) is believed to occur through the generation and repair of DNA double-strand breaks (DSBs) in the long and repetitive switch regions. Although implied, the role of the major vertebrate DSB repair pathway, nonhomologous end joining (NHEJ), in...

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Detalles Bibliográficos
Autores principales: Han, Li, Yu, Kefei
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585838/
https://www.ncbi.nlm.nih.gov/pubmed/19001141
http://dx.doi.org/10.1084/jem.20081623

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