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Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes
Observations that dendritic cells (DCs) constitutively enter afferent lymphatic vessels in many organs and that DCs in some tissues, such as the lung, turnover rapidly in the steady state have led to the concept that a major fraction of lymph node DCs are derived from migratory DCs that enter the ly...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585843/ https://www.ncbi.nlm.nih.gov/pubmed/18981237 http://dx.doi.org/10.1084/jem.20081430 |
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author | Jakubzick, Claudia Bogunovic, Milena Bonito, Anthony J. Kuan, Emma L. Merad, Miriam Randolph, Gwendalyn J. |
author_facet | Jakubzick, Claudia Bogunovic, Milena Bonito, Anthony J. Kuan, Emma L. Merad, Miriam Randolph, Gwendalyn J. |
author_sort | Jakubzick, Claudia |
collection | PubMed |
description | Observations that dendritic cells (DCs) constitutively enter afferent lymphatic vessels in many organs and that DCs in some tissues, such as the lung, turnover rapidly in the steady state have led to the concept that a major fraction of lymph node DCs are derived from migratory DCs that enter the lymph node through upstream afferent lymphatic vessels. We used the lysozyme M–Cre reporter mouse strain to assess the relationship of lymph node and nonlymphoid organ DCs. Our findings challenge the idea that a substantial proportion of lymph node DCs derive from the upstream tissue during homeostasis. Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus. |
format | Text |
id | pubmed-2585843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25858432009-05-24 Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes Jakubzick, Claudia Bogunovic, Milena Bonito, Anthony J. Kuan, Emma L. Merad, Miriam Randolph, Gwendalyn J. J Exp Med Articles Observations that dendritic cells (DCs) constitutively enter afferent lymphatic vessels in many organs and that DCs in some tissues, such as the lung, turnover rapidly in the steady state have led to the concept that a major fraction of lymph node DCs are derived from migratory DCs that enter the lymph node through upstream afferent lymphatic vessels. We used the lysozyme M–Cre reporter mouse strain to assess the relationship of lymph node and nonlymphoid organ DCs. Our findings challenge the idea that a substantial proportion of lymph node DCs derive from the upstream tissue during homeostasis. Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus. The Rockefeller University Press 2008-11-24 /pmc/articles/PMC2585843/ /pubmed/18981237 http://dx.doi.org/10.1084/jem.20081430 Text en © 2008 Jakubzick et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Articles Jakubzick, Claudia Bogunovic, Milena Bonito, Anthony J. Kuan, Emma L. Merad, Miriam Randolph, Gwendalyn J. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title | Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title_full | Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title_fullStr | Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title_full_unstemmed | Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title_short | Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
title_sort | lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585843/ https://www.ncbi.nlm.nih.gov/pubmed/18981237 http://dx.doi.org/10.1084/jem.20081430 |
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