Tpl2 kinase regulates T cell interferon-γ production and host resistance to Toxoplasma gondii

Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically expressed serine-threonine kinase. Tpl2 is known to have critical functions in innate immunity in regulating tumor necrosis factor–α, Toll-like receptor, and G protein–coupled receptor signaling; however, our understa...

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Detalles Bibliográficos
Autores principales: Watford, Wendy T., Hissong, Bruce D., Durant, Lydia R., Yamane, Hidehiro, Muul, Linda M., Kanno, Yuka, Tato, Cristina M., Ramos, Haydeé L., Berger, Alan E., Mielke, Lisa, Pesu, Marko, Solomon, Benjamin, Frucht, David M., Paul, William E., Sher, Alan, Jankovic, Dragana, Tsichlis, Philip N., O'Shea, John J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585846/
https://www.ncbi.nlm.nih.gov/pubmed/19001140
http://dx.doi.org/10.1084/jem.20081461

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