Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues

Voltage-dependent K(+) channels transfer the voltage sensor movement into gate opening or closure through an electromechanical coupling. To test functionally whether an interaction between the S4-S5 linker (L45) and the cytoplasmic end of S6 (S6(T)) constitutes this coupling, the L45 in hKv1.5 was r...

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Detalles Bibliográficos
Autores principales: Labro, Alain J., Raes, Adam L., Grottesi, Alessandro, Van Hoorick, Diane, Sansom, Mark S.P., Snyders, Dirk J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585865/
https://www.ncbi.nlm.nih.gov/pubmed/19029374
http://dx.doi.org/10.1085/jgp.200810048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585865/
https://www.ncbi.nlm.nih.gov/pubmed/19029374
http://dx.doi.org/10.1085/jgp.200810048

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