Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

BACKGROUND: Major Clostridium difficile virulence factors are the exotoxins TcdA and TcdB. Due to the large size and poor stability of the proteins, the active recombinant TcdA and TcdB have been difficult to produce. RESULTS: The toxin genes tcdA and tcdB were amplified by PCR using chromosomal DNA...

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Detalles Bibliográficos
Autores principales: Yang, Guilin, Zhou, Boping, Wang, Jufang, He, Xiangyun, Sun, Xingmin, Nie, Weijia, Tzipori, Saul, Feng, Hanping
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586027/
https://www.ncbi.nlm.nih.gov/pubmed/18990232
http://dx.doi.org/10.1186/1471-2180-8-192

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