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The Ras-association domain family (RASSF) members and their role in human tumourigenesis
Ras proteins play a direct causal role in human cancer with activating mutations in Ras occurring in ∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in Ras effectors, notably B-Raf and PI3-K, and drugs blocking elements of these pathways are in clinical development. In...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Pub. Co
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586335/ https://www.ncbi.nlm.nih.gov/pubmed/17692468 http://dx.doi.org/10.1016/j.bbcan.2007.06.003 |