Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor

The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediate...

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Detalles Bibliográficos
Autores principales: Wang, LiMei, Rahn, Jennifer J, Lun, XueQing, Sun, Beichen, Kelly, John J. P, Weiss, Samuel, Robbins, Stephen M, Forsyth, Peter A, Senger, Donna L
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586378/
https://www.ncbi.nlm.nih.gov/pubmed/19067488
http://dx.doi.org/10.1371/journal.pbio.0060289

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