Hairpin ribozyme-antisense RNA constructs can act as molecular lassos

We have developed a novel class of antisense agents, RNA Lassos, which are capable of binding to and circularizing around complementary target RNAs. The RNA Lasso consists of a fixed sequence derived from the hairpin ribozyme and an antisense segment whose size and sequence can be varied to base pai...

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Detalles Bibliográficos
Autores principales: Dallas, Anne, Balatskaya, Svetlana V., Kuo, Tai-Chih, Ilves, Heini, Vlassov, Alexander V., Kaspar, Roger L., Kisich, Kevin O., Kazakov, Sergei A., Johnston, Brian H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588507/
https://www.ncbi.nlm.nih.gov/pubmed/18953032
http://dx.doi.org/10.1093/nar/gkn637

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