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Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L

The C-terminal domains of Dnmt3a and Dnmt3L form elongated heterotetramers (3L-3a-3a-3L). Analytical ultracentrifugation confirmed the Dnmt3a-C/3L-C complex exists as a 2:2 heterotetramer in solution. The 3a–3a interface is the DNA-binding site, while both interfaces are essential for AdoMet binding...

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Detalles Bibliográficos
Autores principales:	Jurkowska, Renata Z., Anspach, Nils, Urbanke, Claus, Jia, Da, Reinhardt, Richard, Nellen, Wolfgang, Cheng, Xiaodong, Jeltsch, Albert
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588524/ https://www.ncbi.nlm.nih.gov/pubmed/18945701 http://dx.doi.org/10.1093/nar/gkn747

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