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Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

BACKGROUND: Due to the global occurrence of multi-drug-resistant malarial parasites (Plasmodium falciparum), the anti-malarial drug most effective against malaria is artemisinin, a natural product (sesquiterpene lactone endoperoxide) extracted from sweet wormwood (Artemisia annua). However, artemisi...

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Detalles Bibliográficos
Autores principales:	Ro, Dae-Kyun, Ouellet, Mario, Paradise, Eric M, Burd, Helcio, Eng, Diana, Paddon, Chris J, Newman, Jack D, Keasling, Jay D
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588579/ https://www.ncbi.nlm.nih.gov/pubmed/18983675 http://dx.doi.org/10.1186/1472-6750-8-83

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