Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.

Enzymically-deglycosylated antibody IgE lost its allergic activity in mouse systemic anaphylaxis, though the IgE kept its antibody activity. IgE antibody obtained from mice treated with a substance extracted from human urine was deglycosylated. This IgE also lost the allergic activity on the systemi...

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Detalles Bibliográficos
Autores principales: Masuda, Y., Akagawa, Y., Hishikawa, Y.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588722/
https://www.ncbi.nlm.nih.gov/pubmed/11501709
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author Masuda, Y.
Akagawa, Y.
Hishikawa, Y.
author_facet Masuda, Y.
Akagawa, Y.
Hishikawa, Y.
author_sort Masuda, Y.
collection PubMed
description Enzymically-deglycosylated antibody IgE lost its allergic activity in mouse systemic anaphylaxis, though the IgE kept its antibody activity. IgE antibody obtained from mice treated with a substance extracted from human urine was deglycosylated. This IgE also lost the allergic activity on the systemic anaphylaxis but kept its antibody activity. These findings strongly suggest that glycosylation of IgE has a close relation to the binding of the Fc receptor and that humans have another antiallergic mechanism: in vivo IgE antibody deglycosylation induced by the substance.
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spelling pubmed-25887222008-11-28 Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine. Masuda, Y. Akagawa, Y. Hishikawa, Y. Yale J Biol Med Research Article Enzymically-deglycosylated antibody IgE lost its allergic activity in mouse systemic anaphylaxis, though the IgE kept its antibody activity. IgE antibody obtained from mice treated with a substance extracted from human urine was deglycosylated. This IgE also lost the allergic activity on the systemic anaphylaxis but kept its antibody activity. These findings strongly suggest that glycosylation of IgE has a close relation to the binding of the Fc receptor and that humans have another antiallergic mechanism: in vivo IgE antibody deglycosylation induced by the substance. Yale Journal of Biology and Medicine 2001 /pmc/articles/PMC2588722/ /pubmed/11501709 Text en
spellingShingle Research Article
Masuda, Y.
Akagawa, Y.
Hishikawa, Y.
Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title_full Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title_fullStr Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title_full_unstemmed Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title_short Another anti-allergic mechanism: antibody IgE deglycosylation induced by a substance extracted from human urine.
title_sort another anti-allergic mechanism: antibody ige deglycosylation induced by a substance extracted from human urine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588722/
https://www.ncbi.nlm.nih.gov/pubmed/11501709
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AT hishikaway anotherantiallergicmechanismantibodyigedeglycosylationinducedbyasubstanceextractedfromhumanurine

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