The effect of fluconazole treatment on tumor necrosis factor-alpha production in murine candidiasis.

That systemic candidiasis increases TNF-alpha has been proved in various studies. In our study, we investigated if fluconazole too, which is used in treatment, has an additional effect on the increase of TNF-alpha. On the sixth day of the experimental infection, it was measured that TNF-alpha levels...

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Detalles Bibliográficos
Autores principales: Kalkanci, Ayse, Kustimur, Semra
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588809/
https://www.ncbi.nlm.nih.gov/pubmed/14580106
Descripción
Sumario:That systemic candidiasis increases TNF-alpha has been proved in various studies. In our study, we investigated if fluconazole too, which is used in treatment, has an additional effect on the increase of TNF-alpha. On the sixth day of the experimental infection, it was measured that TNF-alpha levels of candidiasis was 699 +/- 60 pg/ml whereas it was 683 +/- 35 pg/ml in the mice that were treated with fluconazole. TNF-alpha levels were measured by enzyme-linked immunosorbant assay. Due to the fact that no statistically significant difference was found between them (p > .05) it was thought that fluconazole did not have an additional effect on the increase of TNF-alpha in candidiasis.

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