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Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.

Cocaine use by pregnant women has been reported to cause fetal and neonatal morbidity and mortality. We hypothesized that human neonates exposed to cocaine via maternal use during pregnancy might manifest changes in beat-to-beat heart rate variability, similar to those described in experimental anim...

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Detalles Bibliográficos
Autores principales: Oriol, N. E., Bennett, F. M., Rigney, D. R., Goldberger, A. L.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588840/
https://www.ncbi.nlm.nih.gov/pubmed/8303912
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author Oriol, N. E.
Bennett, F. M.
Rigney, D. R.
Goldberger, A. L.
author_facet Oriol, N. E.
Bennett, F. M.
Rigney, D. R.
Goldberger, A. L.
author_sort Oriol, N. E.
collection PubMed
description Cocaine use by pregnant women has been reported to cause fetal and neonatal morbidity and mortality. We hypothesized that human neonates exposed to cocaine via maternal use during pregnancy might manifest changes in beat-to-beat heart rate variability, similar to those described in experimental animals. In this preliminary report, we present findings from the first systematic analysis of heart rate dynamics in a small group of (n = 5) neonates exposed in utero to cocaine compared to gestationally age matched controls (n = 6) without known drug exposure. Overall heart rate spectral power during ten minute periods of quiescent sleep was significantly reduced (p < 0.01) in the cocaine-exposed group, reminiscent of the changes recently reported in an animal model. In two other cocaine-exposed newborns, a quiescent sleep period could not be found. We discuss the special methodological problems associated with collection and interpretation of such data.
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spelling pubmed-25888402008-12-01 Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems. Oriol, N. E. Bennett, F. M. Rigney, D. R. Goldberger, A. L. Yale J Biol Med Research Article Cocaine use by pregnant women has been reported to cause fetal and neonatal morbidity and mortality. We hypothesized that human neonates exposed to cocaine via maternal use during pregnancy might manifest changes in beat-to-beat heart rate variability, similar to those described in experimental animals. In this preliminary report, we present findings from the first systematic analysis of heart rate dynamics in a small group of (n = 5) neonates exposed in utero to cocaine compared to gestationally age matched controls (n = 6) without known drug exposure. Overall heart rate spectral power during ten minute periods of quiescent sleep was significantly reduced (p < 0.01) in the cocaine-exposed group, reminiscent of the changes recently reported in an animal model. In two other cocaine-exposed newborns, a quiescent sleep period could not be found. We discuss the special methodological problems associated with collection and interpretation of such data. Yale Journal of Biology and Medicine 1993 /pmc/articles/PMC2588840/ /pubmed/8303912 Text en
spellingShingle Research Article
Oriol, N. E.
Bennett, F. M.
Rigney, D. R.
Goldberger, A. L.
Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title_full Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title_fullStr Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title_full_unstemmed Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title_short Cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
title_sort cocaine effects on neonatal heart rate dynamics: preliminary findings and methodological problems.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588840/
https://www.ncbi.nlm.nih.gov/pubmed/8303912
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