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Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur.
The cartilaginous epiphysis of the distal femur is vascularized by a network of cartilage canals during prenatal development. The vascular invasion of the epiphysis begins at approximately eight to ten weeks of gestation with the initiation of cartilage canal formation. A complex vascular system dev...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Yale Journal of Biology and Medicine
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588871/ https://www.ncbi.nlm.nih.gov/pubmed/8209555 |
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author | Burkus, J. K. Ganey, T. M. Ogden, J. A. |
author_facet | Burkus, J. K. Ganey, T. M. Ogden, J. A. |
author_sort | Burkus, J. K. |
collection | PubMed |
description | The cartilaginous epiphysis of the distal femur is vascularized by a network of cartilage canals during prenatal development. The vascular invasion of the epiphysis begins at approximately eight to ten weeks of gestation with the initiation of cartilage canal formation. A complex vascular system develops within the canals and is well defined by fourteen weeks of gestation. The vascular system is fully developed several months prior to the development of the secondary center of ossification. The formation of the secondary center of ossification within the distal femoral epiphysis is preceded by changes that occur simultaneously within both the chondrocytes in the central portion of the epiphysis and the vascular and perivascular elements contained within the cartilage canals in the central portion of the epiphysis. These concurrent changes in the cellular morphology of the central chondrocytes and in the cellular structure of the central cartilage canals appear to be linked with the initiation of the process of osteogenesis. |
format | Text |
id | pubmed-2588871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-25888712008-12-01 Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. Burkus, J. K. Ganey, T. M. Ogden, J. A. Yale J Biol Med Research Article The cartilaginous epiphysis of the distal femur is vascularized by a network of cartilage canals during prenatal development. The vascular invasion of the epiphysis begins at approximately eight to ten weeks of gestation with the initiation of cartilage canal formation. A complex vascular system develops within the canals and is well defined by fourteen weeks of gestation. The vascular system is fully developed several months prior to the development of the secondary center of ossification. The formation of the secondary center of ossification within the distal femoral epiphysis is preceded by changes that occur simultaneously within both the chondrocytes in the central portion of the epiphysis and the vascular and perivascular elements contained within the cartilage canals in the central portion of the epiphysis. These concurrent changes in the cellular morphology of the central chondrocytes and in the cellular structure of the central cartilage canals appear to be linked with the initiation of the process of osteogenesis. Yale Journal of Biology and Medicine 1993 /pmc/articles/PMC2588871/ /pubmed/8209555 Text en |
spellingShingle | Research Article Burkus, J. K. Ganey, T. M. Ogden, J. A. Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title | Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title_full | Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title_fullStr | Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title_full_unstemmed | Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title_short | Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
title_sort | development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588871/ https://www.ncbi.nlm.nih.gov/pubmed/8209555 |
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