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Helicobacter pylori and hormones.

Helicobacter pylori affects gastric acid secretion via several mechanisms. One of these is by changing gastric regulatory physiology. The infection elevates plasma gastrin levels and decreases gastric mucosal expression of the inhibitory peptide somatostatin. These changes may be due to products of...

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Detalles Bibliográficos
Autor principal: Calam, J.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588979/
https://www.ncbi.nlm.nih.gov/pubmed/9041688
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author Calam, J.
author_facet Calam, J.
author_sort Calam, J.
collection PubMed
description Helicobacter pylori affects gastric acid secretion via several mechanisms. One of these is by changing gastric regulatory physiology. The infection elevates plasma gastrin levels and decreases gastric mucosal expression of the inhibitory peptide somatostatin. These changes may be due to products of H. pylori itself or inflammatory cytokines released in H. pylori infection: acid secretion is inhibited less by a low intra-gastric pH, infusions of cholecystokinin and gastric distention in infected persons. Eradication of H. pylori rapidly decreases basal acid secretion and gastrin-releasing, peptide-stimulated acid secretion. There are now reports that maximally-stimulated acid secretion, a measure of the parietal cell mass, falls significantly six and 12 months after eradication of H. pylori from duodenal ulcer patients. This might be due to withdrawal of the trophic effect of gastrin. However H. pylori can also decrease gastric acid secretion, both through the mechanisms described in Dr. Cave's paper and by causing gastric mucosal atrophy with loss of parietal cells. The net effect on acid presumably depends on which mechanism predominates. The processes involved may be crucial determinants of clinical outcome. For example, infection with little atrophy and high acid secretion is associated with duodenal ulcers, while infection with atrophy and low acid secretion increases the risk of gastric cancer of the intestinal-type.
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spelling pubmed-25889792008-12-01 Helicobacter pylori and hormones. Calam, J. Yale J Biol Med Research Article Helicobacter pylori affects gastric acid secretion via several mechanisms. One of these is by changing gastric regulatory physiology. The infection elevates plasma gastrin levels and decreases gastric mucosal expression of the inhibitory peptide somatostatin. These changes may be due to products of H. pylori itself or inflammatory cytokines released in H. pylori infection: acid secretion is inhibited less by a low intra-gastric pH, infusions of cholecystokinin and gastric distention in infected persons. Eradication of H. pylori rapidly decreases basal acid secretion and gastrin-releasing, peptide-stimulated acid secretion. There are now reports that maximally-stimulated acid secretion, a measure of the parietal cell mass, falls significantly six and 12 months after eradication of H. pylori from duodenal ulcer patients. This might be due to withdrawal of the trophic effect of gastrin. However H. pylori can also decrease gastric acid secretion, both through the mechanisms described in Dr. Cave's paper and by causing gastric mucosal atrophy with loss of parietal cells. The net effect on acid presumably depends on which mechanism predominates. The processes involved may be crucial determinants of clinical outcome. For example, infection with little atrophy and high acid secretion is associated with duodenal ulcers, while infection with atrophy and low acid secretion increases the risk of gastric cancer of the intestinal-type. Yale Journal of Biology and Medicine 1996 /pmc/articles/PMC2588979/ /pubmed/9041688 Text en
spellingShingle Research Article
Calam, J.
Helicobacter pylori and hormones.
title Helicobacter pylori and hormones.
title_full Helicobacter pylori and hormones.
title_fullStr Helicobacter pylori and hormones.
title_full_unstemmed Helicobacter pylori and hormones.
title_short Helicobacter pylori and hormones.
title_sort helicobacter pylori and hormones.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588979/
https://www.ncbi.nlm.nih.gov/pubmed/9041688
work_keys_str_mv AT calamj helicobacterpyloriandhormones