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Regulation of organic anion transport in the liver.
In several liver diseases the biliary transport is disturbed, resulting in, for example, jaundice and cholestasis. Many of these symptoms can be attributed to altered regulation of hepatic transporters. Organic anion transport, mediated by the canalicular multispecific organic anion transporter (cmo...
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yale Journal of Biology and Medicine
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589340/ https://www.ncbi.nlm.nih.gov/pubmed/9626764 |
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author | Roelofsen, H. Müller, M. Jansen, P. L. |
author_facet | Roelofsen, H. Müller, M. Jansen, P. L. |
author_sort | Roelofsen, H. |
collection | PubMed |
description | In several liver diseases the biliary transport is disturbed, resulting in, for example, jaundice and cholestasis. Many of these symptoms can be attributed to altered regulation of hepatic transporters. Organic anion transport, mediated by the canalicular multispecific organic anion transporter (cmoat), has been extensively studied. The regulation of intracellular vesicular sorting of cmoat by protein kinase C and protein kinase A, and the regulation of cmoat-mediated transport in endotoxemic liver disease, have been examined. The discovery that the multidrug resistance protein (MRP), responsible for multidrug resistance in cancers, transports similar substrates as cmoat led to the cloning of a MRP homologue from rat liver, named mrp2. Mrp2 turned out to be identical to cmoat. At present there is evidence that at least two mrp's are present in hepatocytes, the original mrp (mrp1) on the lateral membrane, and mrp2 (cmoat) on the canalicular membrane. The expression of mrp1 and mrp2 in hepatocytes appears to be cell-cycle-dependent and regulated in a reciprocal fashion. These findings show that biliary transport of organic anions and possibly other canalicular transport is influenced by the entry of hepatocytes into the cell cycle. The cloning of the gene for cmoat opens up new possibilities to study the regulation of hepatic organic anion transport. |
format | Text |
id | pubmed-2589340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-25893402008-12-01 Regulation of organic anion transport in the liver. Roelofsen, H. Müller, M. Jansen, P. L. Yale J Biol Med Research Article In several liver diseases the biliary transport is disturbed, resulting in, for example, jaundice and cholestasis. Many of these symptoms can be attributed to altered regulation of hepatic transporters. Organic anion transport, mediated by the canalicular multispecific organic anion transporter (cmoat), has been extensively studied. The regulation of intracellular vesicular sorting of cmoat by protein kinase C and protein kinase A, and the regulation of cmoat-mediated transport in endotoxemic liver disease, have been examined. The discovery that the multidrug resistance protein (MRP), responsible for multidrug resistance in cancers, transports similar substrates as cmoat led to the cloning of a MRP homologue from rat liver, named mrp2. Mrp2 turned out to be identical to cmoat. At present there is evidence that at least two mrp's are present in hepatocytes, the original mrp (mrp1) on the lateral membrane, and mrp2 (cmoat) on the canalicular membrane. The expression of mrp1 and mrp2 in hepatocytes appears to be cell-cycle-dependent and regulated in a reciprocal fashion. These findings show that biliary transport of organic anions and possibly other canalicular transport is influenced by the entry of hepatocytes into the cell cycle. The cloning of the gene for cmoat opens up new possibilities to study the regulation of hepatic organic anion transport. Yale Journal of Biology and Medicine 1997 /pmc/articles/PMC2589340/ /pubmed/9626764 Text en |
spellingShingle | Research Article Roelofsen, H. Müller, M. Jansen, P. L. Regulation of organic anion transport in the liver. |
title | Regulation of organic anion transport in the liver. |
title_full | Regulation of organic anion transport in the liver. |
title_fullStr | Regulation of organic anion transport in the liver. |
title_full_unstemmed | Regulation of organic anion transport in the liver. |
title_short | Regulation of organic anion transport in the liver. |
title_sort | regulation of organic anion transport in the liver. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589340/ https://www.ncbi.nlm.nih.gov/pubmed/9626764 |
work_keys_str_mv | AT roelofsenh regulationoforganicaniontransportintheliver AT mullerm regulationoforganicaniontransportintheliver AT jansenpl regulationoforganicaniontransportintheliver |