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Transfusion-associated graft-versus-host disease.
The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraf...
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Formato: | Texto |
Lenguaje: | English |
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Yale Journal of Biology and Medicine
1990
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589351/ https://www.ncbi.nlm.nih.gov/pubmed/2293503 |
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author | Rappeport, J. M. |
author_facet | Rappeport, J. M. |
author_sort | Rappeport, J. M. |
collection | PubMed |
description | The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign. |
format | Text |
id | pubmed-2589351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-25893512008-11-28 Transfusion-associated graft-versus-host disease. Rappeport, J. M. Yale J Biol Med Research Article The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign. Yale Journal of Biology and Medicine 1990 /pmc/articles/PMC2589351/ /pubmed/2293503 Text en |
spellingShingle | Research Article Rappeport, J. M. Transfusion-associated graft-versus-host disease. |
title | Transfusion-associated graft-versus-host disease. |
title_full | Transfusion-associated graft-versus-host disease. |
title_fullStr | Transfusion-associated graft-versus-host disease. |
title_full_unstemmed | Transfusion-associated graft-versus-host disease. |
title_short | Transfusion-associated graft-versus-host disease. |
title_sort | transfusion-associated graft-versus-host disease. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589351/ https://www.ncbi.nlm.nih.gov/pubmed/2293503 |
work_keys_str_mv | AT rappeportjm transfusionassociatedgraftversushostdisease |