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Transfusion-associated graft-versus-host disease.

The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraf...

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Detalles Bibliográficos
Autor principal: Rappeport, J. M.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589351/
https://www.ncbi.nlm.nih.gov/pubmed/2293503
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author Rappeport, J. M.
author_facet Rappeport, J. M.
author_sort Rappeport, J. M.
collection PubMed
description The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign.
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spelling pubmed-25893512008-11-28 Transfusion-associated graft-versus-host disease. Rappeport, J. M. Yale J Biol Med Research Article The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign. Yale Journal of Biology and Medicine 1990 /pmc/articles/PMC2589351/ /pubmed/2293503 Text en
spellingShingle Research Article
Rappeport, J. M.
Transfusion-associated graft-versus-host disease.
title Transfusion-associated graft-versus-host disease.
title_full Transfusion-associated graft-versus-host disease.
title_fullStr Transfusion-associated graft-versus-host disease.
title_full_unstemmed Transfusion-associated graft-versus-host disease.
title_short Transfusion-associated graft-versus-host disease.
title_sort transfusion-associated graft-versus-host disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589351/
https://www.ncbi.nlm.nih.gov/pubmed/2293503
work_keys_str_mv AT rappeportjm transfusionassociatedgraftversushostdisease