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Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.

Over the last decade, it has become evident that homologous transfusions carry immunologic consequences beyond the well-understood ones of alloimmunization to blood cell antigens. Transfusions constitute temporary transplants of large amounts of allogeneic antigen given intravenously and cause down-...

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Detalles Bibliográficos
Autores principales: Blumberg, N., Heal, J. M.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589357/
https://www.ncbi.nlm.nih.gov/pubmed/2293502
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author Blumberg, N.
Heal, J. M.
author_facet Blumberg, N.
Heal, J. M.
author_sort Blumberg, N.
collection PubMed
description Over the last decade, it has become evident that homologous transfusions carry immunologic consequences beyond the well-understood ones of alloimmunization to blood cell antigens. Transfusions constitute temporary transplants of large amounts of allogeneic antigen given intravenously and cause down-regulation of many cellular immune functions. These changes may explain in part the association of transfusion with such clinically important events as (1) improved survival of renal allografts, (2) decreased recurrence rates for autoimmune disease, (3) increased frequency and earlier recurrences of solid tumors, (4) increased frequency of post-operative bacterial infection, and (5) increased severity of viral infection. Preliminary data suggest that, in animal models and clinical settings, syngeneic or autologous transfusions are not associated with such events. This finding supports the hypothesis that these associations are cause and effect and involve immunologic mechanisms.
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spelling pubmed-25893572008-11-28 Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection. Blumberg, N. Heal, J. M. Yale J Biol Med Research Article Over the last decade, it has become evident that homologous transfusions carry immunologic consequences beyond the well-understood ones of alloimmunization to blood cell antigens. Transfusions constitute temporary transplants of large amounts of allogeneic antigen given intravenously and cause down-regulation of many cellular immune functions. These changes may explain in part the association of transfusion with such clinically important events as (1) improved survival of renal allografts, (2) decreased recurrence rates for autoimmune disease, (3) increased frequency and earlier recurrences of solid tumors, (4) increased frequency of post-operative bacterial infection, and (5) increased severity of viral infection. Preliminary data suggest that, in animal models and clinical settings, syngeneic or autologous transfusions are not associated with such events. This finding supports the hypothesis that these associations are cause and effect and involve immunologic mechanisms. Yale Journal of Biology and Medicine 1990 /pmc/articles/PMC2589357/ /pubmed/2293502 Text en
spellingShingle Research Article
Blumberg, N.
Heal, J. M.
Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title_full Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title_fullStr Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title_full_unstemmed Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title_short Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
title_sort transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589357/
https://www.ncbi.nlm.nih.gov/pubmed/2293502
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