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Post-bone marrow transplant patient management.

Increasingly, bone marrow transplant (BMT) is the treatment of choice for certain hematologic diseases. BMT is, however, a risky procedure with many potentially serious complications. Some complications are the result of the conditioning regimen, a stage of transplantation that includes large doses...

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Detalles Bibliográficos
Autor principal: Poliquin, C. M.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589364/
https://www.ncbi.nlm.nih.gov/pubmed/2293508
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author Poliquin, C. M.
author_facet Poliquin, C. M.
author_sort Poliquin, C. M.
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description Increasingly, bone marrow transplant (BMT) is the treatment of choice for certain hematologic diseases. BMT is, however, a risky procedure with many potentially serious complications. Some complications are the result of the conditioning regimen, a stage of transplantation that includes large doses of chemotherapy and/or radiation therapy. Conditioning-induced neutropenia and thrombocytopenia often result in infection, bleeding, and mucositis. Veno-occlusive disease (VOD), a chemotherapy-induced hepatotoxicity, can cause a mild to severe form of liver disease. Other complications are directly attributable to the engrafted new marrow. Graft-versus-host disease, a rejection process initiated by immunocompetent donor T lymphocytes, is a complication frequently observed in allogeneic BMT. Approximately 14-28 days after the day of transplant, signs of engraftment begin to appear. When specific discharge criteria are met, the BMT patient is discharged from the hospital. Specific follow-up medical care is ongoing for about one year after BMT.
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spelling pubmed-25893642008-11-28 Post-bone marrow transplant patient management. Poliquin, C. M. Yale J Biol Med Research Article Increasingly, bone marrow transplant (BMT) is the treatment of choice for certain hematologic diseases. BMT is, however, a risky procedure with many potentially serious complications. Some complications are the result of the conditioning regimen, a stage of transplantation that includes large doses of chemotherapy and/or radiation therapy. Conditioning-induced neutropenia and thrombocytopenia often result in infection, bleeding, and mucositis. Veno-occlusive disease (VOD), a chemotherapy-induced hepatotoxicity, can cause a mild to severe form of liver disease. Other complications are directly attributable to the engrafted new marrow. Graft-versus-host disease, a rejection process initiated by immunocompetent donor T lymphocytes, is a complication frequently observed in allogeneic BMT. Approximately 14-28 days after the day of transplant, signs of engraftment begin to appear. When specific discharge criteria are met, the BMT patient is discharged from the hospital. Specific follow-up medical care is ongoing for about one year after BMT. Yale Journal of Biology and Medicine 1990 /pmc/articles/PMC2589364/ /pubmed/2293508 Text en
spellingShingle Research Article
Poliquin, C. M.
Post-bone marrow transplant patient management.
title Post-bone marrow transplant patient management.
title_full Post-bone marrow transplant patient management.
title_fullStr Post-bone marrow transplant patient management.
title_full_unstemmed Post-bone marrow transplant patient management.
title_short Post-bone marrow transplant patient management.
title_sort post-bone marrow transplant patient management.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589364/
https://www.ncbi.nlm.nih.gov/pubmed/2293508
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