A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.

We have used the forward mutation to resistance to 6 azauracil to test the mutagenicity of rivanol (6,9 diamino 2-ethoxy acridine) on Escherichia coli. Rivanol has been used to induce therapeutic abortions in midpregnancy and is considered safe and effective for this purpose. The findings reported h...

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Detalles Bibliográficos
Autores principales: Wugmeister, M., Summers, W. C.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589568/
https://www.ncbi.nlm.nih.gov/pubmed/6410594
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author Wugmeister, M.
Summers, W. C.
author_facet Wugmeister, M.
Summers, W. C.
author_sort Wugmeister, M.
collection PubMed
description We have used the forward mutation to resistance to 6 azauracil to test the mutagenicity of rivanol (6,9 diamino 2-ethoxy acridine) on Escherichia coli. Rivanol has been used to induce therapeutic abortions in midpregnancy and is considered safe and effective for this purpose. The findings reported here that rivanol, like other acridines, is a mutagen, at least in procaryotes, suggests that such use of rivanol be reconsidered in light of its possible genetic toxicity.
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spelling pubmed-25895682008-11-28 A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient. Wugmeister, M. Summers, W. C. Yale J Biol Med Research Article We have used the forward mutation to resistance to 6 azauracil to test the mutagenicity of rivanol (6,9 diamino 2-ethoxy acridine) on Escherichia coli. Rivanol has been used to induce therapeutic abortions in midpregnancy and is considered safe and effective for this purpose. The findings reported here that rivanol, like other acridines, is a mutagen, at least in procaryotes, suggests that such use of rivanol be reconsidered in light of its possible genetic toxicity. Yale Journal of Biology and Medicine 1983 /pmc/articles/PMC2589568/ /pubmed/6410594 Text en
spellingShingle Research Article
Wugmeister, M.
Summers, W. C.
A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title_full A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title_fullStr A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title_full_unstemmed A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title_short A bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
title_sort bacterial mutagenicity study of rivanol, an acridine derivative used as an abortifacient.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589568/
https://www.ncbi.nlm.nih.gov/pubmed/6410594
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AT wugmeisterm bacterialmutagenicitystudyofrivanolanacridinederivativeusedasanabortifacient
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