Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.

Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in com...

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Detalles Bibliográficos
Autores principales: Rosenthal, S. A., Hait, W. N.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590415/
https://www.ncbi.nlm.nih.gov/pubmed/2452522
Descripción
Sumario:Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy.

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