Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.

Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in com...

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Detalles Bibliográficos
Autores principales: Rosenthal, S. A., Hait, W. N.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590415/
https://www.ncbi.nlm.nih.gov/pubmed/2452522
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author Rosenthal, S. A.
Hait, W. N.
author_facet Rosenthal, S. A.
Hait, W. N.
author_sort Rosenthal, S. A.
collection PubMed
description Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy.
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spelling pubmed-25904152008-11-28 Potentiation of DNA damage and cytotoxicity by calmodulin antagonists. Rosenthal, S. A. Hait, W. N. Yale J Biol Med Research Article Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy. Yale Journal of Biology and Medicine 1988 /pmc/articles/PMC2590415/ /pubmed/2452522 Text en
spellingShingle Research Article
Rosenthal, S. A.
Hait, W. N.
Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title_full Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title_fullStr Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title_full_unstemmed Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title_short Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
title_sort potentiation of dna damage and cytotoxicity by calmodulin antagonists.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590415/
https://www.ncbi.nlm.nih.gov/pubmed/2452522
work_keys_str_mv AT rosenthalsa potentiationofdnadamageandcytotoxicitybycalmodulinantagonists
AT haitwn potentiationofdnadamageandcytotoxicitybycalmodulinantagonists

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