Cargando…
Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review.
Numerous case reports and retrospective studies suggest an association between M. pneumoniae respiratory infection and extrapulmonary complications, the most common of which involve the central nervous system. There is insufficient evidence based on prospective, carefully controlled observations to...
Autor principal: | |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yale Journal of Biology and Medicine
1983
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590510/ https://www.ncbi.nlm.nih.gov/pubmed/6433568 |
_version_ | 1782161327874113536 |
---|---|
author | Fernald, G. W. |
author_facet | Fernald, G. W. |
author_sort | Fernald, G. W. |
collection | PubMed |
description | Numerous case reports and retrospective studies suggest an association between M. pneumoniae respiratory infection and extrapulmonary complications, the most common of which involve the central nervous system. There is insufficient evidence based on prospective, carefully controlled observations to confirm this association at the present time. A variety of mechanisms has been suggested to explain the involvement of distant organ systems. These include metastatic infection, autoimmunity, toxin generation, and altered host immunity. While none of these is based on evidence to prove an association, the state of anergy which accompanies M. pneumoniae pneumonia deserves consideration and further study as the most plausible link between infecting organisms and extrapulmonary manifestations. |
format | Text |
id | pubmed-2590510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1983 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-25905102008-11-28 Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. Fernald, G. W. Yale J Biol Med Research Article Numerous case reports and retrospective studies suggest an association between M. pneumoniae respiratory infection and extrapulmonary complications, the most common of which involve the central nervous system. There is insufficient evidence based on prospective, carefully controlled observations to confirm this association at the present time. A variety of mechanisms has been suggested to explain the involvement of distant organ systems. These include metastatic infection, autoimmunity, toxin generation, and altered host immunity. While none of these is based on evidence to prove an association, the state of anergy which accompanies M. pneumoniae pneumonia deserves consideration and further study as the most plausible link between infecting organisms and extrapulmonary manifestations. Yale Journal of Biology and Medicine 1983 /pmc/articles/PMC2590510/ /pubmed/6433568 Text en |
spellingShingle | Research Article Fernald, G. W. Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title | Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title_full | Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title_fullStr | Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title_full_unstemmed | Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title_short | Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review. |
title_sort | immunologic mechanisms suggested in the association of m. pneumoniae infection and extrapulmonary disease: a review. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590510/ https://www.ncbi.nlm.nih.gov/pubmed/6433568 |
work_keys_str_mv | AT fernaldgw immunologicmechanismssuggestedintheassociationofmpneumoniaeinfectionandextrapulmonarydiseaseareview |